Polymorphonuclear neutrophil function in systemic sclerosis.
نویسندگان
چکیده
منابع مشابه
Enterocyte function in progressive systemic sclerosis
As a measure of enterocyte function, the deconjugation of pteroyl-L-glutamyl-y-Lglutamyl-y-L-glutamic acid to folic acid and subsequent active absorption was measured in 19 patients with progressive systemic sclerosis and compared with 14 controls. The absorption step of folic acid was identical in the two groups, while deconjugation of pteroyl-L-glutamyl-y-L-glutamyly-L-glutamic acid was signi...
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In progressive systemic sclerosis, sometimes referred to as generalized scleroderma, atrophic and sclerotic changes in the skin and internal organs are usually preceded by Raynaud's phenomenon. The disorder, which affects women more frequently than men, forms one of the socalled collagen vascular diseases and, although the aetiology is uncertain, there is evidence to suggest that auto-immune me...
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Background: Systemic sclerosis is an autoimmune connective tissue disorder which is characterised by cutaneous and internal organ fibrosis. Raynaud’s phenomenon is the earliest feature and may precede the onset of the disease by months to years. The heart, lungs, gastrointestinal tract, kidneys and other organs may be involved. Our aim was to evaluate skin thickness and echogenicity in systemic...
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BACKGROUND Previous in vitro studies have demonstrated that the host response to intra-abdominal infection produces increased generalized polymorphonuclear neutrophil (PMN) adherence to vascular endothelial cells (ECs), which may lead to subsequent endothelial damage, leaky capillaries, and organ dysfunction. There are scant data to demonstrate this enhanced systemic PMN adherence in vivo or th...
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In this study the programmed cell death (apoptosis) of human neutrophilic granulocytes was investigated in the presence and absence of fetal calf serum (FCS), cycloheximide and actinomycin-D. The results show that when FCS is omitted from cultures, apart from a decrease in viability, the percentage of apoptotic cells and DNA fragmentation increases. Apoptosis is accelerated in serum withdra...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1987
ISSN: 0003-4967
DOI: 10.1136/ard.46.4.302